Comparative Effectiveness Research
Assess how treatments perform against available alternatives in real-world settings.
Determining What Works Best in Real-World Practice
Clinical trials often demonstrate efficacy against placebo or controlled comparators. However, decision-makers frequently need evidence comparing treatment alternatives within routine healthcare settings.
Comparative Effectiveness Research (CER) evaluates the relative benefits and risks of different healthcare interventions.
Common Research Questions
- Which treatment produces better outcomes?
- What are the differences in healthcare utilization?
- Which patients benefit most?
- How do therapies perform in specific subgroups?
Methodologies
Propensity Score Matching
Create balanced comparison groups.
Inverse Probability Weighting
Reduce treatment-selection bias.
Multivariable Regression
Adjust for confounding factors.
Time-to-Event Analyses
Assess outcome occurrence over time.
Deliverables
What you receive at the end of a comparative effectiveness study.
How treatments compare when used in routine care.
Tables, figures and text ready for journal submission.
Differences in clinical outcomes between treatment groups.
Costs and resource use compared across treatments.
Related Services
PharmacoepidemiologyEvaluate medication utilization, effectiveness, safety, adherence, and treatment outcomes in real-world populations.Learn more
Safety StudiesMonitor and evaluate real-world safety outcomes across healthcare populations.Learn more
Disease Burden StudiesQuantify the clinical, humanistic, and economic impact of diseases.Learn moreFrequently Asked Questions
Short answers about epidemiology and real-world research.
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Our epidemiologists can talk through your research question and data needs.
What is comparative effectiveness research?
Comparative effectiveness research evaluates the relative benefits and risks of different healthcare interventions as they are used in routine care.
How does comparative effectiveness research differ from an RCT?
A randomized controlled trial compares treatments under controlled conditions. Comparative effectiveness research compares alternatives in everyday practice, often using real-world data.
What is propensity score matching?
Propensity score matching pairs patients with similar characteristics who received different treatments, creating balanced comparison groups in observational data.
What is inverse probability weighting?
Inverse probability weighting gives each patient a weight based on their chance of receiving their treatment, reducing treatment-selection bias.
What is a time-to-event analysis?
A time-to-event analysis studies how long it takes for an outcome to occur, such as hospitalization or progression, while accounting for follow-up time.
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